BACTERIAL TRANSLOCATION IN CLINICAL INTESTINAL TRANSPLANTATION

Bacterial translocation in clinical intestinal transplantation.

BACKGROUND Bacterial translocation (BT) has been suggested to be responsible for the high incidence of infections occurring after small bowel transplantation (SBTx). Bacterial overgrowth, alteration of the mucosal barrier function as a consequence of preservation injury or acute rejection (AR), and potent immunosuppression are all associated with BT. The aim of this study was to evaluate and qu...

Clinical intestinal transplantation.

The advent of tacrolimus allowed clinical intestinal transplantation to become a feasible procedure for patients with irreversible intestinal failure. Over last 5 years, 71 patients underwent intestinal transplantation. Forty-one recipients were children, and 30 recipients were adults. Twenty-five patients received an isolated intestinal graft, 34 patients received a combined liver-intestinal g...

Clinical intestinal transplantation in 1998: Pittsburgh experience.

The massive lymphoid content, and the heavy bacterial load of the gut provided formidable barriers to intestinal transplantation in humans until the clinical introduction of tacrolimus in 1989. After successful preclinical studies, large scale trials were successfully undertaken at our Institution in 1990. To improve outcome and cost effectiveness of the procedure, we conducted an outcome analy...

On Lactobacillus plantarum 299v, Bacterial Translocation and Intestinal Permeability

Clinical intestinal transplantation: focus on complications.

NINE intestinal transplants (three adults. six childrenl have been performed at the University of Pittsburgh since the advent of FK 506. Eight patients had a combined liver-intestinal transplant. one had a solitary intestinal graft. Four of these were performed 3 to 5 weeks before this report. the other five are presented with 5to 16-month follow-ups. The clinical profiles of the patients at tr...